反应详情

A solution of i-PrMgCl (17.3 mL of a 2 M solution in THF, 1.75 equiv) was added slowly to a solution of the 103 (8.0 g, 19.7 mmol) in toluene (160 mL) at −78 C. The solution was aged for 1.5 h then transferred by cannula to a flask containing DMF (2.3 mL, 1.5 equiv) in toluene (30 mL). The solution was quenched with aqueous NH4Cl, and diluted with EtOAc. The organic layer was separated, washed with brine, dried, and evaporated. The crude product was purified by SiO2 by chromatography eluting with 20% EtOAc/hexanes to afford 6.5 g (98%) of 3-(6-bromo-2-fluoro-3-formyl-phenoxy)-5-chloro-benzonitrile (105) as a yellow solid.

1. customthen transferred by cannula to a flask
2. customThe solution was quenched with aqueous NH4Cl
3. additiondiluted with EtOAc
4. customThe organic layer was separated
5. washwashed with brine
6. customdried
7. customevaporated
8. customThe crude product was purified by SiO2 by chromatography
9. washeluting with 20% EtOAc/hexanes