Diethyl Ether → HCID 66998064, compound

HRID 559236Notes

Reaction equation

HRID 559236 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:27](=[O:28])[N:26]([CH3:29])[C:12]2[N:13]([CH3:25])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[NH:21][N:22]=[CH:23][CH:24]=1)=[CH:16][CH:15]=3.[CH:30]([N:33]=[C:34]=[O:35])([CH3:32])[CH3:31].CCOCC>C(Cl)(Cl)Cl>[CH:30]([NH:33][C:34]([N:22]1[CH:23]=[CH:24][C:20]([C:17]2[CH:18]=[C:19]3[C:14](=[CH:15][CH:16]=2)[N:13]([CH3:25])[C:12]2[N:26]([CH3:29])[C:27](=[O:28])[C:9]([C:3]4[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=4[Cl:1])=[CH:10][C:11]3=2)=[N:21]1)=[O:35])([CH3:32])[CH3:31]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 61277Isopropyl isocyanateHCID 16226262HCID 16226262, compound

Product 1

HCID 66998064HCID 66998064, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

100 mg (0.24 mmol) of compound from Example 39, 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(2H-pyrazol-3-yl)-1,9-dihydropyrido[2,3-b]indol-2-one, are dissolved in 4 ml of chloroform. 232 μl (2.36 mmol) of isopropyl isocyanate are added and the mixture is then refluxed for 16 hours. The reaction medium is left to cool and then Et2O is added, and the mixture is filtered and washed with a minimum amount of Et2O.

Workup

  1. temperaturethe mixture is then refluxed for 16 hours
  2. waitThe reaction medium is left
  3. temperatureto cool
  4. filtrationthe mixture is filtered
  5. washwashed with a minimum amount of Et2O

Sources & evidence

ORD record
ord-553446d79000465b80ca0160546fc762
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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