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HRID559287

反应详情

EQUATION

反应方程式

HRID 559287 反应方程式

REACTANTS

反应物

3
Potassium Carbonate 分子结构式
HCID11430

Potassium Carbonate

CK2O3

4-Cyanobenzaldehyde 分子结构式
HCID66042

4-Cyanobenzaldehyde

C8H5NO

Dimethyl (2-oxopropyl)phosphonate 分子结构式
HCID77872

Dimethyl (2-oxopropyl)phosphonate

C5H11O4P

PRODUCTS

产物

1
4-[(1E)-3-Oxo-1-buten-1-yl]benzonitrile 分子结构式
HCID11126721

4-[(1E)-3-Oxo-1-buten-1-yl]benzonitrile

C11H9NO

收率 72%

AUXILIARIES

试剂、催化剂与溶剂

1
Water 分子结构式
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

A two necked flask was charged with 4-formyl-benzonitrile (20.0 g, 0.152 mol) and (2-oxo-propyl)-phosphonic acid dimethyl ester (30.4 g, 0.18 mol) and cooled down at 0° C. K2CO3 (42.16 g, 0.305 mol) in H2O (45 mL) was added dropwise. Stirring was continued over night at RT. The product was extracted with EtOAc, and the organic phase was dried over Na2SO4. Flash chromatography (SiO2, Heptane/EtOAc 1:1) afforded 18.7 g (72%) of the title compound as alight yellow solid.

WORKUP

后处理

  1. waitwas continued over night at RT
  2. extractionThe product was extracted with EtOAc
  3. dry with materialthe organic phase was dried over Na2SO4