Sodium hydride → HCID 59278443, compound

HRID 559736Notes

Reaction equation

HRID 559736 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[H-].[Na+].[CH3:12][NH:13][S:14]([CH3:17])(=[O:16])=[O:15]>C1COCC1.O>[C:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:13]([CH3:12])[S:14]([CH3:17])(=[O:16])=[O:15])[N:7]=1)#[N:9]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 97632N-MethylmethanesulfonamideHCID 2466472-Chloropyrimidine-4-carbonitrile

Product 1

HCID 59278443HCID 59278443, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-chloropyrimidine-4-carbonitrile (0.20 g, 1.43 mmol) in THF was 60% NaH (0.05 g, 2.00 mmol) in mineral oil. After 20 minutes, N-methylmethanesulfonamide (0.22 g, 2.00 mmol) was added. After 3 hours, the reaction was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography eluting with 30% ethyl acetate in heptane. The major fractions were combined and the solvent was concentrated in vacuo to afford N-(4-cyano-pyrimidin-2-yl)-N-methyl-methanesulfonamide.

Workup

  1. waitAfter 3 hours
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by silica gel chromatography
  7. washeluting with 30% ethyl acetate in heptane
  8. concentrationthe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-899e012f65f349c984d06e7e55a7cebc
Source dataset
uspto-grants-2011_11
Patent number
US08063065B2

Reaction notes

Loading…