Methylamine → HCID 59732902, compound

HRID 559990Notes

Reaction equation

[F:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[C:8]=2[C:9](O)=[O:10])=[C:4]([NH:20][C:21]([NH:23][C:24]2[S:25][CH:26]=[CH:27][N:28]=2)=[O:22])[CH:3]=1.[CH3:29][NH2:30].C1COCC1>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[C:8]=2[C:9]([NH:30][CH3:29])=[O:10])=[C:4]([NH:20][C:21]([NH:23][C:24]2[S:25][CH:26]=[CH:27][N:28]=2)=[O:22])[CH:3]=1

Participants

Reactant 3

HCID 6329Methylamine

HCID 8028Tetrahydrofuran

HCID 86593077HCID 86593077, compound

Product 1

HCID 59732902HCID 59732902, compoundYield 72%

Procedure

2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxy-N-methyl-benzamide (150 mg, 72%) was prepared from 2-[4-fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxy-benzoic acid (201 mg, 0.5 mmol) and 1N solution of methyl amine in THF (0.5 mL, 0.5 mmol) following the general procedure K.

Sources & evidence

ORD record: ord-d49b3ad6048a4ec5887d0ee3a910957b
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063081B2

Reaction notes

Loading…