反应详情

To a suspension of 300 mg of N-[2-(3,5-dichloropyridin-2-yl)-2-(hydroxyimino)ethyl]-2-(trifluoromethyl)benzamide and 315 mg of potassium carbonate in 3 ml of N,N-dimethylformamide, 195 mg of 2-iodopropane was added, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, the reaction mixture was mixed with 20 ml of water and extracted with ethyl acetate (10 ml×2), the resulting organic layers were combined, washed with water (10 ml×2), the resulting organic layer was dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 1:9 to 3:7) as the eluent to obtain 258 mg of the desired product as white crystals.

1. additionwas added
2. customAfter completion of the reaction
3. extractionextracted with ethyl acetate (10 ml×2)
4. washwashed with water (10 ml×2)
5. dry with materialthe resulting organic layer was dried over saturated aqueous sodium chloride
6. customanhydrous sodium sulfate, and the solvent was evaporated under reduced pressure
7. customThe resulting residue was purified by silica gel column chromatography