Hydrochloric Acid → HCID 67001255, compound

HRID 560126Notes

Reaction equation

HRID 560126 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])[CH:10]([C:21]2[CH:22]=[C:23]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([S:33]([CH3:36])(=[O:35])=[O:34])[CH:28]=3)[CH:24]=[CH:25][CH:26]=2)[CH2:9]1)=O)(C)(C)C.[ClH:37]>C(O)C>[ClH:37].[CH3:36][S:33]([C:29]1[CH:28]=[C:27]([C:23]2[CH:24]=[CH:25][CH:26]=[C:21]([CH:10]3[CH2:9][NH:8][CH2:13][CH2:12][N:11]3[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH3:20])[CH:22]=2)[CH:32]=[CH:31][CH:30]=1)(=[O:34])=[O:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44549018HCID 44549018, compound

Product 1

HCID 67001255HCID 67001255, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3-(3′-methanesulfonyl-biphenyl-3-yl)-4-o-tolyl-piperazine-1-carboxylic acid tert-butyl ester (90 mg) in ethanol (1 mL) was treated with a saturated solution of HCl in ethanol (1 mL) at room temperature overnight. The solution was concentrated in vacuo to yield crude 2-(3′-methanesulfonyl-biphenyl-3-yl)-1-o-tolyl-piperazine hydrochloride, MS: 407.3 (M+H)+.

Workup

  1. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-73ab7cabd5ae48fdb3aef616ad88bcc0
Source dataset
uspto-grants-2011_11
Patent number
US08063088B2

Reaction notes

Loading…