Hydrochloric Acid → HCID 67000300, compound

HRID 560182Notes

Reaction equation

HRID 560182 reaction equation
[C:1]([NH:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]([C:19]([OH:21])=[O:20])=[C:13]2[CH2:22][CH2:23][CH2:24][NH:25]C(OC(C)(C)C)=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>O1CCOCC1.C(Cl)Cl>[ClH:33].[C:1]([NH:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]([C:19]([OH:21])=[O:20])=[C:13]2[CH2:22][CH2:23][CH2:24][NH2:25])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67000231HCID 67000231, compound

Product 1

HCID 67000300HCID 67000300, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

The above carboxylic acid (31 mg) was dissolved in 5 mL of 4N HCl in dioxane. Within 2 min a white precipitate had formed. The mixture was stirred for 45 min and then diluted with 10 mL of methylene chloride. The solid was filtered with a filter-tipped cannula and washed with 2×10 mL of methylene chloride. The solid was dried under vacuum to provide the title compound; MS, electrospray, 339 (M+H)

Workup

  1. customWithin 2 min a white precipitate had formed
  2. filtrationThe solid was filtered with a filter-tipped cannula
  3. washwashed with 2×10 mL of methylene chloride
  4. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-ca126e47f38c4b96abfe9c897066d934
Source dataset
uspto-grants-2011_11
Patent number
US08063094B2

Reaction notes

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