Hydrochloric Acid → HCID 66999370, compound

HRID 560184Notes

Reaction equation

HRID 560184 reaction equation
[NH:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9]([C:14]([OH:16])=[O:15])=[C:8]2[CH2:17][CH2:18][CH2:19][NH:20]C(OC(C)(C)C)=O)[C:2]([NH2:4])=[O:3].[ClH:28]>O1CCOCC1>[ClH:28].[NH:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9]([C:14]([OH:16])=[O:15])=[C:8]2[CH2:17][CH2:18][CH2:19][NH2:20])[C:2]([NH2:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66999878HCID 66999878, compound

Product 1

HCID 66999370HCID 66999370, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The above carboxylic acid (31 mg) was dissolved in 10 mL of 4N HCl in dioxane. The mixture was spun on the rotovap without vacuum for 45 min. The solid was filtered with a filter-tipped cannula and washed with 2×10 mL of methylene chloride. The solid was dried under vacuum to yield the title compound (21 mg); MS, electrospray, 278 (M+H).

Workup

  1. filtrationThe solid was filtered with a filter-tipped cannula
  2. washwashed with 2×10 mL of methylene chloride
  3. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-3789a9d366c047fdbdad12e7ff97ad73
Source dataset
uspto-grants-2011_11
Patent number
US08063094B2

Reaction notes

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