Cyclobutanone → 1-Pyrrolidin-1-yl-cyclobutanecarbonitrile

HRID 560193Notes

Reaction equation

[N:1]1([C:6]2([C:10]#[N:11])[CH2:9]O[CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:12]1(=O)CCC1.N1CCCC1>>[N:1]1([C:6]2([C:10]#[N:11])[CH2:9][CH2:12][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 3

HCID 14496Cyclobutanone

HCID 31268Pyrrolidine

HCID 591979193-Cyano-3-(pyrrolidin-1-YL)oxetane

Product 1

HCID 438027731-Pyrrolidin-1-yl-cyclobutanecarbonitrile

Procedure

The title compound, colorless liquid, MS: m/e=151.1 [(M+H)+], was prepared in accordance with the general method of intermediate A from cyclobutanone and pyrrolidine.

Sources & evidence

ORD record: ord-017087a471024d1da670f79899c52229
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

Loading…