Dimethylamine, hydrochloride → 1-(Dimethylamino)cyclobutanecarbonitrile

HRID 560203Notes

Reaction equation

[N:1]1([C:6]2([C:10]#[N:11])[CH2:9]O[CH2:7]2)[CH2:5]CC[CH2:2]1.[C:12]1(=O)CCC1.Cl.CNC>>[CH3:5][N:1]([CH3:2])[C:6]1([C:10]#[N:11])[CH2:7][CH2:12][CH2:9]1

Participants

Reactant 3

HCID 10473Dimethylamine, hydrochloride

HCID 14496Cyclobutanone

HCID 591979193-Cyano-3-(pyrrolidin-1-YL)oxetane

Product 1

HCID 107491771-(Dimethylamino)cyclobutanecarbonitrile

Procedure

The title compound, colorless liquid, MS: m/e=125.1 [(M+H)+], was prepared in accordance with the general method of intermediate A from cyclobutanone and dimethylamine hydrochloride.

Sources & evidence

ORD record: ord-4f735b5783644926bcbbb539831a6f88
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

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