Benzyl Bromide → HCID 58031484, compound

HRID 560584Notes

Reaction equation

C(Br)C1C=CC=CC=1.I[CH2:10][CH2:11][CH2:12][CH3:13].[CH3:14][C:15]1[N:16]=[C:17]([N:25]2[CH2:29][CH2:28][NH:27][C:26]2=[O:30])[S:18][C:19]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[CH2:10]([N:27]1[CH2:28][CH2:29][N:25]([C:17]2[S:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:15]([CH3:14])[N:16]=2)[C:26]1=[O:30])[CH2:11][CH2:12][CH3:13]

Participants

Reactant 3

HCID 7498Benzyl Bromide

HCID 10962Butyl iodide

HCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 58031484HCID 58031484, compoundYield 73%

Procedure

Following the procedure as described in Example 5, making variations to replace benzyl bromide with 1-iodobutane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 73% yield: NMR (300 MHZ, CDCl3) δ 4.08 (q, J=7.2 Hz, 2H), 3.99-3.85 (m, 2H), 3.47-3.33 (m, 2H), 3.11 (t, J=7.5 Hz, 2H), 2.38 (s, 3H), 1.41-1.22 (m, 7H), 0.74 (t, J=7.2 Hz, 3H); MS (ES+) m/z 312.3 (M+1).

Sources & evidence

ORD record: ord-ae7595a7da9b49159daa3683a7a72637
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063084B2

Reaction notes

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