反应详情

温度

80 °C

A mixture of methyl bromoacetate (11.25 ml, 116 mmol) and sodium 4-chloro-benzenesulfinate (25.2 g, 116 mmol) in DMF (120 ml) was stirred and heated at 80° C. for 2 h. The solution was diluted with water (360 ml). The separated oil was extracted with chloroform (200 ml) and washed with water (3×80 ml). The organic phase was evaporated in vacuo to obtain 22.4 g of the title compound in 77.7% yield.

1. extractionThe separated oil was extracted with chloroform (200 ml)
2. washwashed with water (3×80 ml)
3. customThe organic phase was evaporated in vacuo