Hydrochloric Acid → HCID 66999992, compound

HRID 561086Notes

Reaction equation

HRID 561086 reaction equation
[ClH:1].[Br:2][C:3]1[CH:28]=[CH:27][C:6]([CH2:7][CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[O:22][CH2:21][CH2:20][C:19]4=[O:26])[CH2:10][CH2:9]2)=[CH:5][C:4]=1[O:29][CH2:30][CH2:31][O:32][CH3:33]>CC(O)C>[ClH:1].[Br:2][C:3]1[CH:28]=[CH:27][C:6]([CH2:7][CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[O:22][CH2:21][CH2:20][C:19]4=[O:26])[CH2:10][CH2:9]2)=[CH:5][C:4]=1[O:29][CH2:30][CH2:31][O:32][CH3:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44182694HCID 44182694, compound

Product 1

HCID 66999992HCID 66999992, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

An aqueous concentrated hydrochloric acid solution (36%, 760 μL, 8.5 mmol) was added at room temperature to a solution of the compound (3.07 g, 5.8 mmol) obtained in Example 3 in 2-propanol (20 mL), and the solution was stirred at room temperature for 15.5 hours. The precipitate was collected by filtration, washed with 2-propanol (2 mL×2), and dried under reduced pressure to obtain the title compound (2.26 g, 72%) as a white powder.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with 2-propanol (2 mL×2)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-74bd897581b441a3ada6f826aded6239
Source dataset
uspto-grants-2011_11
Patent number
US08063223B2

Reaction notes

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