反应详情

A solution of NaH (5.61 g, 140 mmol, 60% in oil) in DMF (300 mL) was cooled to 0° C. and treated dropwise with ethyl 3-(tert-butylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate (42.02 g, 117 mmol) in DMF (100 mL). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was poured into ice water and the resulting precipitate was removed by filtration, washed with water and then dried to yield ethyl 1-tert-butyl-6,7-difluoro-1,4-dihydro-8-methoxy4-oxoquinoline-3-carboxylate (38.9 g, 98%) as a pale yellow solid.

1. customthe resulting precipitate was removed by filtration
2. washwashed with water
3. customdried