反应详情

A solution of 1.48 g (3.36 mmol) of the compound from Example 39A in 20 ml of tetrahydrofuran was added dropwise to 11.8 ml (11.8 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 50 ml of tetrahydrofuran at RT under argon. The mixture was stirred at RT for 15 min and then 1N hydrochloric acid was added. The mixture was extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate, filtered and concentrated. 1.32 g (99% of theory) of the title compound were obtained.

1. extractionThe mixture was extracted with ethyl acetate
2. dry with materialthe organic phase was dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated