反应详情

温度

80 °C

14 mg (0.21 mmol) of potassium cyanide were added to 50 mg (0.11 mmol) of the compound from Example 69A in 1 ml of DMF. The mixture was stirred at 80° C. for 5 h, water was added to the reaction solution, and the aqueous phase was extracted twice with dichloromethane. The combined organic phases were dried over sodium sulfate, the solid was filtered off, and the solvents were removed. The crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 38 mg (89% of theory) of the target compound were obtained.

1. extractionthe aqueous phase was extracted twice with dichloromethane
2. dry with materialThe combined organic phases were dried over sodium sulfate
3. filtrationthe solid was filtered off
4. customthe solvents were removed
5. customThe crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)
6. custom38 mg (89% of theory) of the target compound were obtained