反应详情

温度

0 °C

To anhydrous THF (35 mL) was added LiAlH4 (3.19 g, 84 mmol) in one portion in an ice bath. The mixture was stirred at 0° C. for 20 min, and a solution of 2-morpholinoacetonitrile (3.50 g, 28 mmol) in anhydrous THF (10 mL) was added dropwise. Upon the end of addition the mixture was refluxed for 3 h, then cooled to rt, diluted with water (20 mL), filtered and concentrated in vacuo to give the title compound as yellow oil (2.62 g, 72%).

1. additionUpon the end of addition the mixture
2. temperaturewas refluxed for 3 h
3. temperaturecooled to rt
4. filtrationfiltered
5. concentrationconcentrated in vacuo