反应详情

温度

80 °C

0.30 g (4.57 mmol) of potassium cyanide was added to 1.05 g (2.28 mmol) of the compound from Example 111A in 21 ml of DMSO. The mixture was stirred at 80° C. for 3 h, ethyl acetate was added to the reaction solution, and the mixture was washed twice with water and once with saturated aqueous sodium chloride solution. The combined organic phases were freed of solvent, and the crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 0.74 g (83% of theory) of the target compound was obtained.

1. washthe mixture was washed twice with water and once with saturated aqueous sodium chloride solution
2. customthe crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)
3. custom0.74 g (83% of theory) of the target compound was obtained