Imidazole → 2-(p-Bromophenoxy)ethanol

HRID 561844Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C1(=O)O[CH2:12][CH2:11][O:10]1.N1C=CN=C1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:12][CH2:11][OH:10])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 795Imidazole

HCID 7303Ethylene carbonate

HCID 78084-Bromophenol

Product 1

HCID 991682-(p-Bromophenoxy)ethanol

Conditions

Temperature: 150 °C

Procedure

4-Bromophenol (1 eq.), ethylene carbonate (1 eq.) and imidazole (0.5% loading) were combined and heated at 150° C. for 2 h to afford the title compound as a brown oil.

Sources & evidence

ORD record: ord-1d77dcdc4b9f40b3805a7005b5fafc53
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063105B2

Reaction notes

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