反应详情

温度

60 °C

A mixture of 2,4-dihydroxy-3-methyl-benzaldehyde (3.31 g, 21.8 mmol), benzylbromide (4.09 g, 23.9 mmol), NaHCO3 (5.49 g, 65.4 mmol), 1,4-dioxane (30 mL) and water (12 mL) was stirred at 60° C. for overnight. Then the reaction mixture was cooled to RT, water (100 mL) was added, extracted with EtOAc (2×200 mL). The extract was dried over Na2SO4, evaporated. The residue was purified on SiO2 (25 g) column, hexane-EtOAc (0 to 5%). Yield 1.57 g (6.48 mmol, 29%) as off-white solid.

1. temperatureThen the reaction mixture was cooled to RT
2. extractionextracted with EtOAc (2×200 mL)
3. dry with materialThe extract was dried over Na2SO4
4. customevaporated
5. customThe residue was purified on SiO2 (25 g) column, hexane-EtOAc (0 to 5%)