反应详情

100 mg (0.3 mmol) of the compound from Example 13A, 58 mg (0.4 mmol) of 3,3-difluoropyrrolidine hydrochloride and 175 μl (130 mg, 1.0 mmol) of N-ethyl-N-(propan-2-yl)propane-2-amine are initially charged in 2 ml of tetrahydrofuran and reacted in a single mode microwave (Emrys Optimizer) at 120° C. for 1 h. After concentration under reduced pressure, the residue is taken up in acetonitrile/water and purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). Yield: 111 mg (99% of theory)

1. customreacted in a single mode microwave (Emrys Optimizer) at 120° C. for 1 h
2. concentrationAfter concentration under reduced pressure
3. custompurified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)