反应详情

100 mg (0.3 mmol) of the compound from Example 13A, 52 mg (0.4 mmol) of 3,3-difluoroazetidine hydrochloride and 175 μl (130 mg, 1.0 mmol) of N-ethyl-N-(propan-2-yl)propane-2-amine are initially charged in 2 ml of tetrahydrofuran and reacted in a single mode microwave (Emrys Optimizer) at 120° C. for 3 h. The precipitated solid is filtered off and the filtrate is concentrated under reduced pressure. The residue is taken up in acetonitrile/water and purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). Yield: 36 mg (32% of theory)

1. customreacted in a single mode microwave (Emrys Optimizer) at 120° C. for 3 h
2. filtrationThe precipitated solid is filtered off
3. concentrationthe filtrate is concentrated under reduced pressure
4. custompurified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)