Water → Dasatinib

HRID 562604Notes

Reaction equation

HRID 562604 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[S:15][C:14]([NH:16][C:17]3[CH:18]=[C:19]([N:24]4[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][OH:32])[CH2:26][CH2:25]4)[N:20]=[C:21]([CH3:23])[N:22]=3)=[N:13][CH:12]=2)=[O:10])=[C:6]([Cl:33])[CH:5]=[CH:4][CH:3]=1.C([O-])(C)C.O>CN(C=O)C>[CH3:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[S:15][C:14]([NH:16][C:17]3[CH:18]=[C:19]([N:24]4[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][OH:32])[CH2:26][CH2:25]4)[N:20]=[C:21]([CH3:23])[N:22]=3)=[N:13][CH:12]=2)=[O:10])=[C:6]([Cl:33])[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 962WaterHCID 86630109Dasatinib i-propanolate

Product 1

HCID 3062316Dasatinib

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Dasatinib i-propanolate (form A3, 4.74 g) was dissolved in DMF (23.7 ml) at 100° C. After water (23.7 ml) was added at 100° C. The suspension was cooled to room temperature. The product was filtered off, washed with water (3×) and dried on the filter.

Workup

  1. filtrationThe product was filtered off
  2. washwashed with water (3×)
  3. customdried on the filter

Sources & evidence

ORD record
ord-ed7feab9fd42490287c07ff87f933101
Source dataset
uspto-grants-2011_11
Patent number
US08067423B2

Reaction notes

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