反应详情

温度

70 °C

A mixture of 3-chlorophenol (2.57 g, 20.0 mmol), 2-bromoacetamide (2.76 g, 20.0 mmol) and K2CO3 (5.53 g, 40.0 mmol) in acetone (40 mL) was stirred at 70° C. overnight. The mixture was then cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (3.22 g, 87%).

1. temperatureThe mixture was then cooled to rt
2. filtrationfiltered
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)