HRID562819

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CCc1cc2c(cc1CC)CC(N(Cc1ccccc1)C[C@H](O)c1ccc(OCc3ccccc3)c([N+](=O)[O-])c1)C2

HCID54308695

未命名化合物

PRODUCTS

产物

反应SMILES：CCc1cc2c(cc1CC)CC(N(Cc1ccccc1)C[C@H](O)c1ccc(OCc3ccccc3)c(N)c1)C2

HCID53799063

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID345198

Platinic oxide

O2Pt

溶剂HCID1140

Toluene

C7H8

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

(R)-2-[Benzyl-(5,6-diethyl-indan-2-yl)-amino]-1-(4-benzyloxy-3-nitro-phenyl)-ethanol (3.00 g) is dissolved in THF (50 mL) and toluene (50 mL). A catalytic amount of PtO2 is added and the solution is stirred under an atmosphere of H2. The reaction is shown to be complete by TLC after 6 hours. The catalyst is filtered off and the solvent is removed in vacuo. The product is not purified further. TLC (silica, n-hexane/ethyl acetate 1:1 Rf=0.75).

WORKUP

后处理

filtrationThe catalyst is filtered off
customthe solvent is removed in vacuo
customThe product is not purified further

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-89ebfb976a48402783d74c0ad5fc1f67
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08067437B2
来源说明: uspto-grants-2011_11

反应SMILES

[CH2:1]([N:8]([CH:29]1[CH2:37][C:36]2[C:31](=[CH:32][C:33]([CH2:40][CH3:41])=[C:34]([CH2:38][CH3:39])[CH:35]=2)[CH2:30]1)[CH2:9][C@@H:10]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:14]([N+:26]([O-])=O)[CH:13]=1)[OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.C1(C)C=CC=CC=1.O=[Pt]=O>[NH2:26][C:14]1[CH:13]=[C:12]([C@@H:10]([OH:11])[CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:29]2[CH2:30][C:31]3[C:36](=[CH:35][C:34]([CH2:38][CH3:39])=[C:33]([CH2:40][CH3:41])[CH:32]=3)[CH2:37]2)[CH:17]=[CH:16][C:15]=1[O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1