反应详情

温度

140 °C

A mixture of 1,2-difluoro-4-nitrobenzene (7.95 g, 50.0 mmol), morpholin-3-one (5.06 g, 50.0 mmol) and K2CO3 (13.82 g, 100 mmol) in DMF (80 mL) was stirred at 140° C. overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=3:1) to give the title compound as a yellow solid (5.00 g, 42%).

1. temperatureThe mixture was cooled to rt
2. filtrationfiltered
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=3:1)