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HRID56337

反应详情

EQUATION

反应方程式

HRID 56337 的结构方程式

REACTANTS

反应物

2
结构：C1CCNCC1
HCID8082

Piperidine

C5H11N

结构：CC(C)(C)OC(=O)CN(CCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)Cc1ccccn1
HCID59408713

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)CN(CCCC[C@H](N)C(=O)O)Cc1ccccn1
HCID67421779

未命名化合物

收率 70%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of PAMA-K (0.600 g, 1.047 mmol) and piperidine (1.0 mL) in DMF (5.0 mL) was stirred at room temperature for 3 hrs. Solvent was evaporated under reduced pressure to give a residue, which was purified by Amberchrom (CG-161C) eluting with MeOH/H2O to give (S)-2-amino-6-((2-tert-butoxy-2-oxoethyl)(pyridin-2-ylmethyl)amino)hexanoic acid (0.256 g, 70%). MS (ESI), 352 (M+H)+.

WORKUP

后处理

  1. customSolvent was evaporated under reduced pressure
  2. customto give a residue, which
  3. customwas purified by Amberchrom (CG-161C)
  4. washeluting with MeOH/H2O