Hydrochloric Acid → HCID 59252795, compound

HRID 563441Notes

Reaction equation

HRID 563441 reaction equation
C([O:4][CH2:5][C:6]([CH:16]([C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[N:28]([C:32]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=1)[N:27]=[CH:26]2)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:15])[C:7]([NH:9][C:10]1[S:11][CH:12]=[N:13][N:14]=1)=[O:8])(=O)C.Cl>CC#N>[F:38][C:35]1[CH:34]=[CH:33][C:32]([N:28]2[C:29]3[C:25](=[CH:24][C:23]([CH:16]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:6]([CH2:5][OH:4])([CH3:15])[C:7]([NH:9][C:10]4[S:11][CH:12]=[N:13][N:14]=4)=[O:8])=[CH:31][CH:30]=3)[CH:26]=[N:27]2)=[CH:37][CH:36]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24937871HCID 24937871, compound

Product 1

HCID 59252795HCID 59252795, compoundYield 7.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Example 155 was prepared from 3-(1,3,4-thiadiazol-2-ylamino)-2-((1-(4-fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)-2-methyl-3-oxopropyl acetate (24 mg, 0.168 mmol) by treating with 1N HCl in CH3CN and heating for 1 hr at reflux. The product was purified by HPLC to give 6 mg of desired product. MS found: (M+H)+=48.

Workup

  1. temperatureheating for 1 hr
  2. temperatureat reflux
  3. customThe product was purified by HPLC

Sources & evidence

ORD record
ord-deddbcc5058147ac8b7624ba5c035d3e
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

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