Cyclopropanecarbonyl chloride → {5-Chloro-2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-fluoro-biphenyl-3-yl}-acetic acid ethyl ester

HRID 563682Notes

Reaction equation

HRID 563682 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:7]=[C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH2:20][NH:21][CH2:22][CH3:23])[CH:9]=[C:10]([Cl:12])[CH:11]=1)[CH3:2].[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:7]=[C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH2:20][N:21]([C:28]([CH:25]2[CH2:27][CH2:26]2)=[O:29])[CH2:22][CH3:23])[CH:9]=[C:10]([Cl:12])[CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 58148881(5-Chloro-2'-ethylaminomethyl-4'-fluoro-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58149054{5-Chloro-2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-fluoro-biphenyl-3-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (5-chloro-2′-ethylaminomethyl-4′-fluoro-biphenyl-3-yl)-acetic acid ethyl ester and cyclopropanecarbonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5d5c884663a8405580402ec938968162
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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