Hydrochloric Acid → methyl 2-(5-bromo-2-fluorophenyl)acetate
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:12])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.Cl.[CH3:14]O>O1CCOCC1>[CH3:14][O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[F:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
To a solution of (5-bromo-2-fluoro-phenyl)-acetic acid (2.3 mmol) in MeOH (15 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.
Workup
- concentrationThe mixture was concentrated
- customthe residue was purified by silica gel chromatography
Sources & evidence
- ORD record
- ord-57f0b91e6881458fa8a9ff486027b708
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08067445B2
Reaction notes
Loading…