反应详情

To a solution of Example 3 (50 mg, 0.128 mmol) in THF (2 mL) was added methyl(triphenylphosphoranylidene)acetate (51 mg, 0.153 mmol). The reaction mixture was stirred for 3 days and then concentrated in vacuo. The resulting residue was purified by ISCO column (4.0 g column, EtOAc/hexane=0-80%, 10 mL/min) to give Example 103 (40.5 mg, 71%) as a yellow solid.

1. concentrationconcentrated in vacuo
2. customThe resulting residue was purified by ISCO column (4.0 g column, EtOAc/hexane=0-80%, 10 mL/min)