2-Bromoethyl ethyl ether → HCID 66744353, compound

HRID 563913Notes

Reaction equation

HRID 563913 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH2:11]([O:13][CH2:14][CH2:15]Br)[CH3:12]>C(O)C>[CH2:11]([O:13][CH2:14][CH2:15][N:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:1][CH3:2])[CH3:12]

Participants

4

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 84352N-Ethylbenzylamine

Product 1

HCID 66744353HCID 66744353, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The synthesis of FEA was carried out in a manner similar to that of BnEO (process 2) using N-ethylbenzylamine (15 mL, 0.101 mol), bromoethyl ethyl ether (17 mL, 0.101×1.5 mol), and ethanol (100 mL) as a solvent. BnEE (12.79 g, 61.69 mmol, yield 61%) was obtained as a pale yellow clear liquid. [Purification was carried out by medium pressure silica gel column chromatography (ethyl acetate:n-hexane=4:1).]

Workup

  1. customThe synthesis of FEA
  2. customBnEE (12.79 g, 61.69 mmol, yield 61%) was obtained as a pale yellow clear liquid
  3. custom[Purification

Sources & evidence

ORD record
ord-99a702cb1231493d90ad9f305de8c434
Source dataset
uspto-grants-2011_11
Patent number
US08067595B2

Reaction notes

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