1-Methylpiperazine → HCID 765903, compound

HRID 564008Notes

Reaction equation

HRID 564008 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12]Br>C1COCC1>[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 699793-Bromobenzyl bromide

Product 1

HCID 765903HCID 765903, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

0.30 g 1-Methylpiperazine in 2 ml THF were treated dropwise at RT with a solution of 0.5 g 3-bromobenzyl bromide in 3 ml THF. After stirring for 2 hrs, the mixture was heated to 60 C for 30 min. The solvent was evaporated and the residue chromatographed on silica using a gradient from heptane to heptane/dichloromethane/conc. ammonia (4/6/0.5).

Workup

  1. temperaturethe mixture was heated to 60 C for 30 min
  2. customThe solvent was evaporated
  3. customthe residue chromatographed on silica using a gradient from heptane to heptane/dichloromethane/conc

Sources & evidence

ORD record
ord-819315acc17a4a6ea659d6d8d517b262
Source dataset
uspto-grants-2011_11
Patent number
US08067599B2

Reaction notes

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