反应详情

To a solution of 700 mg 3-(1-Cyano-ethyl)-benzoic acid in 20 ml dichloromethane were added dropwise 610 mg oxalyl chloride and 2 drops of DMF at RT. After stirring for 1 hr, 10 ml ethanol were added and stirring was continued for another hr. The solvents were evaporated, the residue dissolved in dichloromethane and washed with aqueous sodium bicarbonate solution. The dichloromethane phase was dried, evaporated and the residue purified by chromatography on silica in ethyl acetate/heptane mixtures.

1. stirringstirring
2. waitwas continued for another hr
3. customThe solvents were evaporated
4. dissolutionthe residue dissolved in dichloromethane
5. washwashed with aqueous sodium bicarbonate solution
6. dry with materialThe dichloromethane phase was dried
7. customevaporated
8. customthe residue purified by chromatography on silica in ethyl acetate/heptane mixtures