Piperidin-4-ol → HCID 58042809, compound

HRID 564155Notes

Reaction equation

HRID 564155 reaction equation
C1CCN(C(CNCC2C=CC3OCOC=3C=2)=S)CC1.Br[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][N:31]2[CH:36]=[CH:35][C:34]([O:37][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[CH:33][C:32]2=[O:44])=[CH:25][CH:24]=1.[OH:45][CH:46]1[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]1>>[OH:45][CH:46]1[CH2:51][CH2:50][N:49]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][N:31]3[CH:36]=[CH:35][C:34]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)=[CH:33][C:32]3=[O:44])=[CH:25][CH:24]=2)[CH2:48][CH2:47]1

Participants

4

Reactant 3

HCID 79341Piperidin-4-olHCID 10334538N-(1,3-benzodioxol-5-ylmethyl)-N-(2-piperidin-1-yl-2-thioxoethyl)amineHCID 670069881-[2-(4-Bromomethyl-phenyl)-ethyl]-4-phenoxy-1H-pyridin-2-one

Product 1

HCID 58042809HCID 58042809, compound

Procedure

1-{2-[4-(4-Hydroxy-piperidin-1-ylmethyl)-phenyl]-ethyl}-4-phenoxy-1H-pyridin-2-one is prepared as example 16.2c from 100 mg (0.26 mmol) 1-[2-(4-bromomethyl-phenyl)-ethyl]-4-phenoxy-1H-pyridin-2-one (example 16.2b) and 105 mg (1.04 mmol) 4-hydroxy-piperidine.

Sources & evidence

ORD record
ord-e5bbebc9e37941058dbe2b5180ad3d29
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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