反应详情

温度

40 °C

To a solution of EXAMPLE 34C (2.4 g) in pyridine (100 mL) and DMF (100 mL) was added CDI (1.6 g). The mixture was heated at 40° C. for 1 hour, treated with 2,3-diaminobenzamide dihydrochloride (1.8 g), stirred at ambient temperature overnight and concentrated. The concentrate was heated in acetic acid (50 mL) at 80° C. overnight and concentrated. The concentrate was flash chromatographed on silica gel with ethyl acetate.

1. concentrationconcentrated
2. temperatureThe concentrate was heated in acetic acid (50 mL) at 80° C. overnight
3. concentrationconcentrated
4. customchromatographed on silica gel with ethyl acetate