Trifluoroacetic acid → (E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid

HRID 564260Notes

Reaction equation

HRID 564260 reaction equation
C([O:5][C:6](=[O:24])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:18]1([CH2:17][S:14]([N:11]2[CH:12]=[CH:13][C:9](/[CH:8]=[CH:7]/[C:6]([OH:24])=[O:5])=[CH:10]2)(=[O:16])=[O:15])[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66646367(E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid tert-butylester2×

Product 1

HCID 66646065(E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Starting materials: (E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid tert-butylester (compound C2) (1.45 g), CH2Cl2 (80 ml), TFA (8 ml). Reaction conditions: room temperature, 2 hours.

Workup

  1. customReaction conditions
  2. customroom temperature, 2 hours

Sources & evidence

ORD record
ord-86ca749fec8d49c388cfee24632dbb43
Source dataset
uspto-grants-2011_11
Patent number
US08067615B2

Reaction notes

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