Methylamine → HCID 178482442, compound

HRID 564845Notes

Reaction equation

HRID 564845 reaction equation
[CH3:1][N:2](C)[C:3]1[O:4][CH:5]([CH:9]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([F:20])=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH3:10])[C:6](=[O:8])[N:7]=1.CN>>[F:20][C:16]1[CH:15]=[C:14]2[C:19]([C:11]([CH:9]([CH:5]3[O:4][C:3]([NH:2][CH3:1])=[N:7][C:6]3=[O:8])[CH3:10])=[CH:12][NH:13]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 18473918HCID 18473918, compound

Product 1

HCID 178482442HCID 178482442, compoundYield 78.5%

Procedure

2-Dimethylamino-5-[1-(6-fluoroindol-3-yl)ethyl]-2-oxazolin-4-one (340 mg) was dissolved into methylamine (5 ml) at −10° C. The mixture was stirred for 3 hours at the same temperature. The mixture was concentrated to give a residue, which was subjected to column chromatography. Elution with hexane-acetone (1:1) provided the titled compound (254 mg).

Workup

  1. concentrationThe mixture was concentrated
  2. customto give a residue, which
  3. washElution with hexane-acetone (1:1)

Sources & evidence

ORD record
ord-e89fedc8cb7648ddbac5b448dd4ad3f5
Source dataset
uspto-grants-2001_01
Patent number
US06169102A

Reaction notes

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