Potassium Carbonate → 3-Chloro-2-hydrazinylpyridine

HRID 564859Notes

Reaction equation

HRID 564859 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11].C(=O)([O-])[O-].[K+].[K+]>C(O)CCC>[Cl:8][C:7]1[C:2]([NH:10][NH2:11])=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 169882,3-DichloropyridineHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 5561003-Chloro-2-hydrazinylpyridineYield 89.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

To 30 ml of an n-butanol solution containing 7.0 g of 2,3-dichloropyridine were added 7.1 g of hydrazine monohydrate and 6.54 g of anhydrous potassium carbonate, and the mixture was heated under reflux for 17.5 hours. After cooling, the precipitate was collected by filtration to yield 6.07 g of the title compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 17.5 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-f6161f601e6e4caba4ff1c5f5d65e7a7
Source dataset
uspto-grants-2001_01
Patent number
US06169086A

Reaction notes

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