Anisole → HCID 18545439, compound

HRID 564873Notes

Reaction equation

HRID 564873 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15]/[CH:16]=[CH:17]/[C:18]3[CH:19]=[N:20][N:21]([C:24]4[N:29]=[C:28]([NH:30]CC5C=CC(OC)=CC=5)[N:27]=[C:26]([NH:40]CC5C=CC(OC)=CC=5)[N:25]=4)[C:22]=3[CH3:23])[CH2:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[ClH:1].[NH2:40][C:26]1[N:27]=[C:28]([NH2:30])[N:29]=[C:24]([N:21]2[C:22]([CH3:23])=[C:18](/[CH:17]=[CH:16]/[CH2:15][N:12]3[CH2:13][CH2:14][N:9]([C:4]4[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Cl:1])[CH:3]=4)[CH2:10][CH2:11]3)[CH:19]=[N:20]2)[N:25]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 59928271HCID 59928271, compound

Product 1

HCID 18545439HCID 18545439, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture consisting of 1.26 g of the compound obtained in Example 54, 50 ml of trifluoroacetic acid, and 0.62 ml of anisole was treated in the same manner as in Example 37 to obtain 420 mg of the title compound.

Workup

  1. additionwas treated in the same manner as in Example 37

Sources & evidence

ORD record
ord-da14bf49c1754a69ace645ced6b0fc7d
Source dataset
uspto-grants-2001_01
Patent number
US06169086A

Reaction notes

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