反应详情

To a solution of N-methylethanolamine (600 mg), in N,N-dimethylformamide were added imidazole (1.13 g) and tert-butyldiphenylsilyl chloride (2.20 g) at ambient temperature with stirring. After 8 hours, the mixture was diluted with water (60 ml) and was extracted with ethyl acetate (20 ml) twice. The organic layer was washed with water three times and brine, dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography eluting with dichloromethane-methanol to give N-(2-tert-butyldiphenylsilyloxyethyl)-N-methylamine (780 mg) as an oil.

1. extractionwas extracted with ethyl acetate (20 ml) twice
2. washThe organic layer was washed with water three times and brine
3. dry with materialdried over magnesium sulfate
4. customThe solvent was removed in vacuo
5. customThe residue was purified by column chromatography
6. washeluting with dichloromethane-methanol