Guanidine Hydrochloride → HCID 178485141, compound

HRID 565045Notes

Reaction equation

HRID 565045 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)=[C:7]2[C:3]=1[CH:4]=[C:5]([C:22](OCC)=[O:23])[N:6]2C.Cl.[NH2:28][C:29]([NH2:31])=[NH:30].[CH3:32][O-].[Na+]>CO>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)=[C:7]2[C:3]=1[CH:4]=[C:5]([C:22]([N:30]=[C:29]([NH2:31])[NH:28][CH3:32])=[O:23])[NH:6]2

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194305Ethyl 4-chloro-1-methyl-7-(3-nitrophenoxy)-2-indolecarboxylate

Product 1

HCID 178485141HCID 178485141, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 186 b) except for using 0.17 g (0.45 mmol) of ethyl 4-chloro-1-methyl-7-(3-nitrophenoxy)-2-indolecarboxylate, 1.30 g of guanidine hydrochloride, 0.74 g (13.6 mmol) of sodium methoxide and 30 ml of methanol. 4-Chloro-1-methyl-7-(3-nitrophenoxy)-2-indoloylguanidine was obtained in the amount of 0.06 g (34.3%).

Sources & evidence

ORD record
ord-228f77c9ddce459c8c0af45dc53cef33
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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