反应详情

To a mixture of 2-bromo-1-(4-(methylsulfonyl)phenyl)propan-1-one (6.0 g, 20.6 mmol) and thiophenoxyacetic acid (3.8 g, 22.6 mmol) in acetonitrile (60 mL) was added triethylamine (4.0 mL, 28.8 mmol). The mixture was stirred at r.t. for 3 h. T.L.C. showed no bromoketone remaining and DBU (4.0 mL) was added. The mixture was stirred at r.t. for 1 h., then air was bubbled through the mixture for another hour. After dilution with water, the mixture was extracted with EtOAc. The EtOAc extract was washed with 1 N aquous HCl, brine, dried over MgSO4, filtered and the solvent evaporated under vacuum. The residue was swished in Et2O to give the title compound (6.0 g) as a pale yellow powder.

1. additionwas added
2. stirringThe mixture was stirred at r.t. for 1 h.
3. customair was bubbled through the mixture for another hour
4. extractionAfter dilution with water, the mixture was extracted with EtOAc
5. extractionThe EtOAc extract
6. washwas washed with 1 N aquous HCl, brine
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customthe solvent evaporated under vacuum