Toluene → HCID 54429791, compound

HRID 565151Notes

Reaction equation

[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14](=[CH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:15](O)=[O:16])[CH:5]=[CH:4][C:3]1=2.C1(C)C=CC=CC=1.S(Cl)([Cl:35])=O>CN(C=O)C>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14](=[CH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:15]([Cl:35])=[O:16])[CH:5]=[CH:4][C:3]1=2

Participants

Conditions

Temperature: 50 °C

Procedure

1.7 g (5 mmol) of 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-nonenoic acid, 20 ml of toluene and 73 μl of DMF were introduced into a round-bottomed flask. The mixture was heated to 50° C. and 714 μl (6 mmol) of thionyl chloride were added and the mixture was stirred at this temperature for one hour. The mixture was evaporated to dryness and the crude acid chloride was employed as is in the synthesis to follow.

Workup

customThe mixture was evaporated to dryness
customas is in the synthesis

Sources & evidence

ORD record: ord-a4d789d00afe4e1ab2b90b06d8b22834
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06171603B2

Reaction notes

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