Hydrochloric Acid → HCID 22725218, compound

HRID 565216Notes

Reaction equation

HRID 565216 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[N:15]([C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)=[O:17])[C:14]([O:28]C)=[N:13][C:12]([CH3:30])=[C:11]2[C:31](=[O:33])[CH3:32])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].Cl>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[N:15]([C:16]([O:18][C:19]3[CH:20]=[CH:21][C:22]([N+:25]([O-:27])=[O:26])=[CH:23][CH:24]=3)=[O:17])[C:14](=[O:28])[NH:13][C:12]([CH3:30])=[C:11]2[C:31](=[O:33])[CH3:32])[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22725169HCID 22725169, compound

Product 1

HCID 22725218HCID 22725218, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a well-stirred solution of 6-(3,4,5-trifluorophenyl)-1,6-dihydro-2-methoxy-5-acetyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (4.0 g, 8.63 mmol) in THF (100 mL) at 0-5° C., 6 N aqueous HCl (4 mL) was added and the mixture was allowed to warm to room temperature. After 2 h, solvent was evaporated and the product dried under vacuum. The title compound was obtained as a pure single component and used un the next step without further purification (3.88 g, 100%).

Workup

  1. customsolvent was evaporated
  2. customthe product dried under vacuum

Sources & evidence

ORD record
ord-e340099cd89d4592b16fbd9c29acb6ec
Source dataset
uspto-grants-2001_01
Patent number
US06172066B2

Reaction notes

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