Ethylenediamine → HCID 21998659, compound

HRID 565224Notes

Reaction equation

HRID 565224 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]([NH2:17])[CH2:15][NH2:16].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[C:1]1([CH:7]2[CH2:12][CH2:11][CH:10]([N:16]=[CH:15][CH2:14][NH2:17])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 6101p-Toluenesulfonic acidHCID 786054-Phenylcyclohexanone

Product 1

HCID 21998659HCID 21998659, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 4-phenylcyclohexanone (4.00 g, 22.96 mmol) and ethylenediamine (1.66 g, 27.5 mmol) and p-toluenesulfonic acid (437 mg) in benzene (200 mL) was refluxed for 4 h in Dean-Stark trap to remove the water that formed. Tlc analysis indicated the completion of the reaction. Solvent was evaporated and the product was used in the next step without any further purification.

Workup

  1. temperaturewas refluxed for 4 h in Dean-Stark trap
  2. customto remove the water
  3. customthat formed
  4. customthe completion of the reaction
  5. customSolvent was evaporated
  6. customthe product was used in the next step without any further purification

Sources & evidence

ORD record
ord-a026a535ca6c47a0b3e201b1ed23061c
Source dataset
uspto-grants-2001_01
Patent number
US06172066B2

Reaction notes

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