Hydrochloric Acid → HCID 69985657, compound

HRID 565372Notes

Reaction equation

HRID 565372 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC1[N:19]([CH:20]2[CH2:25][CH2:24][N:23]([C:26]3([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH2:32][CH2:31][CH:30]=[CH:29][CH2:28][CH2:27]3)[CH2:22][CH2:21]2)[C:18]2[CH:39]=[CH:40][CH:41]=[CH:42][C:17]=2[N:16]=1.Cl>>[C:33]1([C:26]2([N:23]3[CH2:24][CH2:25][CH:20]([N:19]4[C:18]5[CH:39]=[CH:40][CH:41]=[CH:42][C:17]=5[N:16]=[C:6]4[N:8]4[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]4)[CH2:21][CH2:22]3)[CH2:32][CH2:31][CH2:30][CH2:29][CH:28]=[CH:27]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 21268115HCID 21268115, compound

Product 1

HCID 69985657HCID 69985657, compoundYield 40.3%

Procedure

This was prepared according to the procedure described in Example 67 using 1-N-t-butoxycarbonylpiperazine instead of 4-t-butoxycarbonylaminopiperidine, and 2-chloro-1-[1-(1-phenyl-4-cyclohepten-1-yl)-4-piperidinyl]benzimidazole as starting material which was prepared in Preparation 9. Overall yield was 40.3%. HCl salt was amorphous solid.

Workup

  1. customThis was prepared
  2. customwas prepared in Preparation 9

Sources & evidence

ORD record
ord-02d84a6b04824c76a01f5282e123c83e
Source dataset
uspto-grants-2001_01
Patent number
US06172067B2

Reaction notes

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