Hydrochloric Acid → HCID 22111032, compound

HRID 565703Notes

Reaction equation

HRID 565703 reaction equation
[NH2:1][C:2]1[C:3]([CH3:44])=[C:4]([CH3:43])[C:5]2[O:9][C:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([N:18]([CH2:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:19][CH2:20][CH:21]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:41]=1[CH3:42].[ClH:45]>C(O)C>[ClH:45].[ClH:45].[ClH:45].[NH2:1][C:2]1[C:3]([CH3:44])=[C:4]([CH3:43])[C:5]2[O:9][C:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([N:18]([CH2:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:19][CH2:20][CH:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:41]=1[CH3:42]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22111033HCID 22111033, compound

Product 1

HCID 22111032HCID 22111032, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-benzyl-N-(3,3-diphenylpropyl)-4-piperidinamine obtained above (1.0 g) was treated with 4N HCl solution in ethanol and the resulting trihydrochloride was recrystallized from ethanol/diethyl ether to provide 0.65 g of the title compound. Yield 53%.

Workup

  1. customthe resulting trihydrochloride was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-530a8c74fec341ab8aaac9d4bbbc723b
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

Loading…