反应详情

In DMF (3ml) was dissolved 7-(4-methylphenyl)-N-[4-(thiomorpholinomethyl)phenyl]-3,4-dihydro-naphthalene-2-carboxamide (160mg), and to the mixture was added methyl iodide (66 μl). The mixture was stirred at room temperature for 17 hours, and to the mixture was added ethyl acetate (100ml). The resulting precipitate was filtered and recrystallized from ethyl acetate-methanol to give 4-methyl-4-[4-[7-(4-methyl-phenyl)-3,4-dihydro-naphthalene-2-carboxamido]benzyl]-thiomorpholinium iodide (Compound 55) (165mg) as colorless crystals.

1. filtrationThe resulting precipitate was filtered
2. customrecrystallized from ethyl acetate-methanol